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Duxcospan Caplets & Tablets


Each tablet contains:

  • Hyoscine butyl bromide B.P 10mg.
  • Paracetamol B.P 500mg.

Pharmacological Properties:
Duxcospan plus tablets is a combination of hyoscine butyl bromide and paracetamol. Hyoscine butyl bromide is a quaternary ammonium derivative with antimuscarinic effects. It exerts a specific antispasmodic action on the smooth muscle of the gastrointestinal, biliary and urinary tracts, this action being produced long before the side-effects, characteristic of stropine-like substance occur.
Paracetamol is a Para-aminophenol derivative, has analgesic and antipyretic properties. It is used in the symptomatic management of pain and fever.

The quaternary derivatives (Hyoscine butyl bromide) are poorly absorbed from the gastrointestinal tract and do not readily pass the blood-brain-barrier. Hyoscine butyl bromide is almost entirely metabolized probably in the liver, only a small proportion of oral dose has been reported to be excreted unchanged in the urine.
Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations ccuring about 10 to 60 minutes after oral administration. It is distributed into most body tissues. It crosses the placenta and is present in breast milk. The administration half-life of the drug varies from about 1 to 3 hours. It is metabolized predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5 % is excreted as unchanged paracetamol.

Paroxysmal pain in diseases of stomach or intestine, spastic pain and functional disorders in the biliary and urinary tract and female genital organs.

Antimuscarinics (Hyoscine butylbromide included) are contraindicated in angle-closure glaucoma, myasthenia gravis (but may be used to decrease muscarinic side effects of acetylcholinesterases), paralytic ileus, pyloric stenosis and prostatic enlargement.

Duxcospan plus should be given with care in patients with impaired kidney or liver function in alcoholism and patients taking other drugs that affect the liver. Absorption of paracetamol content in Duxcospan plus may be accelerated by metoclopramide. Excretion of paracetamol may be affected and plasma concentrations altered when administered with probenecid. Duxcospan plus should be given with caution in patients with Myasthenia gravis, renal and hhepatic impairment, diarrhea, glaucoma, hypertension, ulcerative colitis and Down Syndrome.

Side Effects:
Gastrointestinal disturbances, staggering, skin rashes, conjunctivitis, anticholinergic side effects such as: dry mouth/skin, difficulty in swallowing, visual disturbances, flushings and drowsiness.
Other adverse reactions include:- liver damage in prolonged use or over dosage.

Dosage and Administration:
1 – 2 tablets 3 times daily.

Blister pack of 2 x 10’s and 10 x 10’s in unit boxes.

Do not store above 30°C. Store in a dry place. Protect from direct sunlight.

About Product

16 September, 2014