Sulfran

Co-Trimoxazole 120mg / 240mg / Syrup 480mg / 960mg

Pharmacological Class:
Sulfur based antibiotic.

Indications:
Treatment & Prevention of Pneuomocystic jivoreci
Treatment of norcadiasis
Use in AECB
UTIs
Prevention of opportunistic infections in immuno-compromised patients.
Treatment of Toxoplasmosis.

Dosage: Adults: 960mg – 2.88g daily in 2 divided doses depending on severity of disease.
Children: 18mg/Kg body weight daily in 2 divided doses

NB// Higher doses of 120mg/Kg body weight daily given in 2 – 4 divided doses for 14 – 21 days in treatment of Pneumocystis Carinii jivoreci.
Prophylaxis of PCP: 960mg PO daily and may be reduced to 480mg daily to improve tolerance or 960mg daily on alternate days .
Children: 6wks – 5mns: 120mg BD for 3 consecutive days or 7 days per week.
6mns – 5yrs: 240mg
6yrs – 12yrs: 480mg

Side Effects: GIT disturbances
– nausea & vomiting;
Kernicterus in new borns; skin rash.